Homeostatic Plasticity: Single Hippocampal Neurons See the Light
نویسنده
چکیده
Neurons adapt to altered network activity through homeostatic changes in synaptic function. In this issue of Neuron, Goold and Nicoll report that chronic hyperactivation of individual CA1 pyramidal neurons drives cell-autonomous, compensatory synapse elimination via CaMKIV-dependent transcription. These findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulation of synaptic inputs.
منابع مشابه
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ورودعنوان ژورنال:
- Neuron
دوره 68 شماره
صفحات -
تاریخ انتشار 2010